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正常双胎和单胎妊娠孕中期母血清的总游离β-人绒毛膜促性腺激素、α-甲胎蛋白和游离雌三醇水平 [中文引用][英文引用]
Second-trimester Maternal Serum Total-β-human Chorionic Gonadotropin α-fetoprotein Levels and unconjuated Estriol 3 Levels in Normal Twin and Singleton Pregnacies
单位(英文)：Cytogenetics lad of O&G department of 1st affiliated hospital of Kunming medical college
分类号：R714.7
出版年·卷·期（页码）：2011·3·第4期（22-25）
DOI:
20110406
-----摘要：-------------------------------------------------------------------------------------------
目的 研究昆明地区单胎妊娠和双胎妊娠母体血清中总游离β-人绒毛膜促性腺激素（total free-β HCG），甲胎蛋白（AFP）和游离雌三醇（uE3）水平的差异。方法 对62名正常双胎妊娠的同期2009名单胎妊娠妇女，在怀孕15-21孕周，用贝克曼Access化学发光系统检测孕妇血清总游离β-HCG、AFP和uE3的水平。在相同孕周下比较单胎和双胎的标志物的水平。结果 研究表明，单胎孕妇血清总游离β-HCG、AFP和uE3水平与双胎之间有明显差异。母血清中总游离β-HCG、AFP和uE3水平与孕期体重在单胎妊娠中具有显著相关性（P﹤0.05）。但在双胎妊娠中，两者之间没有显著相关性。结论 不同孕周母血清总游离β-HCG、AFP和uE3水平在正常双胎妊娠中的水平并非单胎妊娠的2倍。用单胎风险计算软件来筛查双胎可能是不合理的。
-----英文摘要：---------------------------------------------------------------------------------------
Objective The compared study the differences of concentration of total free-β HCG, AFP and uE3 in maternal serum between singleton and twin pregnancies in local region of Kunming. Methods The level of total free-β HCG, AFP and uE3 in maternal serum in 62 normal twin pregnancies and 2009 singleton pregnancies at gestational weeks from15 to 21 were measured by Access Immunoassay system of Beckman Coulter. The level of markers were compared between the twins and singletons in specific gestations. Results Significant differences were found between the levels of total free-β HCG, AFP and uE3 in twins and twice of those in singletons. There was significant correlation between the levels of maternal serum total free-β HCG, AFP and uE3 and maternal weights (P<0.05) in most gestational weeks (from16w to 20w). While, in twin pregnancies there were no significant correlations between them. Conclusion The gestational age-specific levels of maternal serum total free-β HCG, AFP and uE3 in normal twin pregnancies are not as twice as those of singletons. The weight-corrections software of singletons may be not reasonable for the screening of twins.
-----参考文献：---------------------------------------------------------------------------------------
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中文著录格式:
钱源,肖雪,鲁玲,张兰,马润玫.正常双胎和单胎妊娠孕中期母血清的总游离β-人绒毛膜促性腺激素、α-甲胎蛋白和游离雌三醇水平.中国产前诊断杂志,2011,3(4):22-25.
英文著录格式:
Qian,Yuan,,Xiao,Xue,,Lu,Ling,,Zhang,Lan,,Ma,Run-mei.Second-trimester Maternal Serum Total-β-human Chorionic Gonadotropin α-fetoprotein Levels and unconjuated Estriol 3 Levels in Normal Twin and Singleton Pregnacies.No Title Settings,2011,3(4):22-25.