广东韶关地区163例男性不育患者Y染色体微缺失分析 [中文引用][英文引用]

目的 探讨Y染色体AZF基因微缺失检测对男性不育患者诊疗的临床意义。方法采用荧光定量PCR法对163例无精或严重少精子患者和50例健康男性进行Y染色体AZF基因微缺失分析。结果 163例男性不育患者中，共检出9例Y染色体微缺失，总检出率为5.52%。包括5例AZFc缺失，3例AZFb+c缺失，1例AZFa+b+c缺失。对照组未检出Y染色体微缺失。两组检出率差异有统计学意义（P<0.05）。结论 开展Y染色体AZF基因微缺失检测对男性不育患者查明病因和指导选择辅助生殖方式具有重要意义。

Objective To explore the clinical significance of Y chromosome AZF gene microdeletions in the diagnosis and treatment of male infertility. Method A total of 163 patients with azoospermia or severe oligozoospermia and 50 healthy men were analyzed for the microdeletions of Y chromosome AZF gene by real-time PCR. Results 9 cases of Y chromosome microdeletions were detected in the 163 male infertility patients, the total detection rate is 5.52%, Including 5 cases of AZFc deletion, 3 cases of AZFb+c deletion, 1 case of AZFa+b+c deletion. No Y chromosome microdeletions were detected in the control group. There was a statistically significant difference in detection rate between the two groups (P<0.05). Conclusions It is great significance to carry out the Y chromosome AZF gene microdeletions to identify the cause and guide the selection of assisted reproductive methods in male infertility patients.