分类号：R446.11
出版年·卷·期（页码）：2019·11·第1期（31-33）
DOI:
10.13470/j.cnki.cjpd.2019.01.007
-----摘要：-------------------------------------------------------------------------------------------
目的 研究唐氏血清学筛查标本在-20℃条件下保存1年的临床可接受性。方法 检测-20℃冰箱保存1年后的中孕期唐氏血清学筛查标本的甲胎蛋白（α-fetoprotein，AFP）、游离人绒毛膜促性腺激素（freeβ-human chorionic gonadotrophin,β-hCG）、游离雌三醇（unconjugated oestriol，uE3）的浓度，与原始浓度进行统计学分析，验证储存条件改变后，3种标志物的浓度是否满足标准要求。结果 复查结果与原始结果无显著性差异，临床可以接受。 结论 -20℃保存唐氏血清学标本可以代替-80℃保存，复查结果可满足临床要求。
-----英文摘要：---------------------------------------------------------------------------------------
Objective To study the clinical acceptability about the samples of serum screening test for the Downs syndromes in pregnancy have been staying in Minus 20 degrees Celsius for one year. Method Test again the α-fetoprotein , freeβ—human chorionic Gonadotrophin and unconjugated oestriol concentration in the specimen of serum screening test for the Downs syndromes in pregnancy have been staying in Minus 20 degrees Celsius for one year. The results of the review were statistically analyzed with the original results, then verify the requirements are met whether or not when the storage conditions were changed. Results There was no significant difference between the review results and the original results, which was clinically acceptable. Conclusions The review results can meet the clinical requirements when Storage conditions by Minus 20 degrees Celsius to Minus 80 degrees Celsius.
-----参考文献：---------------------------------------------------------------------------------------
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冉健,裴元元,胡亮,温丽娟,魏凤香.唐氏中孕血清学筛查标本-20℃保存1年后结果比对与临床可接受性评价.中国产前诊断杂志,2019,11(1):31-33.
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