分类号：R714.51
出版年·卷·期（页码）：2013·5·第3期（29-31）
DOI:
20130307
-----摘要：-------------------------------------------------------------------------------------------
目的 研究孕妇血栓前状态对胎儿生长受限（fetal growth restriction，FGR）及新生儿结局的影响。方法 观察2010年1月至2012年12月在本院按期产检、无合并症的第一胎孕妇共732人，发现胎儿生长受限（FGR）42例，自愿接受低分子肝素治疗的患者11例为研究1组；继续观察并在本院分娩的14例为研究2组；同期正常分娩孕妇14例为对照组。比较：①各组孕28～32周、36周及分娩前凝血功能，包括红细胞压积(HCT)、血小板计数(PLT)、凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)；②新生儿出生孕周及体重。结果 ①孕32周：研究1组血小板计数(PLT)明显低于对照组，P=0.004，P<0.05，差异有统计学意义；②孕36周：研究1组血小板计数(PLT)与研究组无差异，但明显低于研究2组，P=0.014，P<0.05；研究1组治疗后与对照组凝血酶原时间(PT)比较有明显差异，有统计学意义，P=0.045，P<0.05；③分娩前：各组间凝血功能无明显差异；④组内比较分娩前与孕32周：研究1组P=0.054，研究2组PLT增加有明显差异性，P=0.046，P<0.05；⑤各组新生儿胎龄无明显差异，P=0.22，P=0.23，P=0.81，P>0.05。各组出生体重比较有明显差异，P=0.002,P=0.033，P=0.002,P <0.05。结论 ①FGR孕妇在孕28～32周前已存在有血栓前状态，导致胎儿宫内生长减缓，低体重儿出生；②低分子肝素治疗可改善FGR患者的血栓前状态，可改善新生儿的妊娠结局。
-----英文摘要：---------------------------------------------------------------------------------------
Objective To explore the effects of thrombophilia on fetal growth restriction(FGR) and newborn outcome. Method 11 cases of FGR enrolled in low-molecular-heparin were in group 1. 14 cases of FGR in study group 2. 14 cases normal pregnant women were in control group 3. Monitor in 32 weeks, 36 weeks and the time before labor: Hematocrit(HCT), blood platelet(PLT), Activated panialthrombopalstin time (APTT), Plasma prothrombin time(PT), Thrombin time(TT); birth weight and embryo age. Results ①32 weeks: The number of PLT in group 1 is lower than group 3, P=0.004.②36 weeks: PT in group 1 is longer than in group 3,P =0.014. ③ There were no differences in three groups at the time before labor. ④Compare 32-weeks with the time before labor: PLT had risen up. Group 1, P =0.054. Group 2, P =0.046. Group 3, P=0.34. ⑤ The gestational age had no difference in three groups. The newborn weight have significantly difference, P=0.002,P=0.033，P=0.002,P <0.05. Conclusions ①Effects of thrombophilia on fetal growth restriction had been existed before 28～32 weeks, and can conduce low birth weight. 2. Low-molecular-heparin can increase the birth weight.
-----参考文献：---------------------------------------------------------------------------------------
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陈晖,姜立新,雷艳爱.孕妇血栓前状态对胎儿生长受限及新生儿结局的影响.中国产前诊断杂志,2013,5(3):29-31.
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