分类号：R714.251
出版年·卷·期（页码）：2015·7·第1期（26-30）
DOI:
10.13470/j.cnki.cjpd.2015.01.006
-----摘要：-------------------------------------------------------------------------------------------
目的 调查南京及其周边地区孕妇人群戊型肝炎病毒（hepatitis E virus, HEV）感染状况。方法 912例中孕期孕妇血清采用ELISA法初筛血清抗-HEV IgG和IgM抗体，初筛阳性血清进一步采用Western blotting确认。结果 南京及其周边地区中孕期孕妇人群抗-HEV IgG抗体阳性率为13.6%（124/912），抗-HEV IgM抗体阳性率为1.4%（13/912）。在<21岁、21～25岁、26～30岁和>30岁孕妇中，抗-HEV IgG阳性率分别为14.0%（6/43）、12.6%（62/492）、15.2%（39/256）、12.1%（17/121）；抗-HEV IgM阳性率分别为2.3%（1/43）、1.0%（5/492）、1.2%（3/256）和3.3%（4/121）；各年龄组抗-HEV IgG和IgM抗体阳性率差异均无统计学意义（P>0.05）。所有抗-HEV IgM阳性血清，同时抗-HEV IgG阳性。结论 南京及其周边地区中孕孕妇人群存在HEV散发感染，以无症状的隐性感染为主。
-----英文摘要：---------------------------------------------------------------------------------------
Objective To investigate the seroprevalence of hepatitis E virus (HEV) infection in pregnant women in Nanjing and the surrounding areas. Method The sera collected from 912 pregnant women at gestation age of 15-21 weeks were tested for anti-HEV IgG and IgM with ELISA and then confirmed by Western blotting. Results The overall prevalence of anti-HEV IgG and anti-HEV IgM in pregnant women were 13.6% (124/912) and 1.4% (13/912), respectively. The positive rates of anti-HEV IgG in the pregnant women at the ages of<21, 21-25, 26-30, and >30 years were 14.0% (6/43), 12.6% (62/492), 15.2% (39/256) and 3.3% (17/121), respectively, and the positive rates of anti-HEV IgM in those four groups were 2.3% (1/43), 1.0% (5/492), 1.2% (3/256), and 1.2% (4/121), respectively; the prevalence of anti-HEV IgG and IgM did not differ significantly among the four age groups (P>0.05). All the anti-HEV IgM positive samples were also IgG positive. Conclusions Sporadic cases of HEV infection in pregnant women were detected in Nanjing and the surrounding areas, mainly with subclinical infections.
-----参考文献：---------------------------------------------------------------------------------------
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周璇,黄红玉,段红蕾,陈珊珊,周乙华,胡娅莉.南京地区中孕孕妇戊型肝炎病毒感染血清流行病学调查.中国产前诊断杂志,2015,7(1):26-30.
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