分类号：R714.23
出版年·卷·期（页码）：2014·6·第4期（11-14）
DOI:
10.13470/j.cnki.cjpd.2014.04.003
-----摘要：-------------------------------------------------------------------------------------------
目的 通过分析近年来本科室双胎妊娠产前诊断结果以探讨双胎产前诊断的安全性及意义。方法 回顾性分析2011年1月1日至2014年2月28日于广东省妇幼保健院医学遗传中心行介入性产前诊断的174例双胎妊娠孕妇资料，分析其产前诊断指征，结果及结局。结果 ①总共对283个胎儿取样，共检出29个异常。异常检出率10.2%（29/283）。其中胎儿预后不良异常15个，异常率5.3%（15/283）。②绒穿组/羊穿组/脐穿组术后2周内流产率分别为 0.0%（0/7）、1.3%（2/149）、0.0%（0/18）；双胎总流产率分别为 14.3%（1/7）、3.4%（5/149）、0.0%（0/18）。结论 介入性产前诊断技术能有效发现胎儿异常，对于符合产前诊断指征双胎孕妇，告知相关手术风险后仍需建议孕妇行相关介入性产前诊断检查。
-----英文摘要：---------------------------------------------------------------------------------------
Objective To investigate the safety of invasive prenatal diagnostic procedures of prenatal diagnosis for twins and its significance. Method This study retrospectively analyzed the 174 twin pregnancies who took invasive prenatal diagnostic procedures guided by ultrasound in Guangdong Women and children’s hospital from 2011-01-01 to 2014-02-08.The indications, results and outcomes of invasive prenatal diagnostic procedures were analyzed. Results ①Totally 283 fetus were examined, and there were 29 abnormal results.?The abnormal detection rate was 10.2% (29/283).There were 15 severely abnormal results. The rate was 5.3% (15/283). ②The fetal loss rate within two weeks after the procedure were 0.0%（0/7）、1.3%（2/149）、0.0%（0/18）respectively in the different group of chorionic villi sampling group /mniocentesis group / cordocentesis group. The total fetal loss rate were 14.3%（1/7）、3.4%（5/149）、0.0%（0/18）respectively. Conclusions Invasive prenatal diagnostic procedures can find fetus with congenital abnormality effectively. Doctors should advice twin pregnancies who had indications to take invasive prenatal diagnostic procedure after warning relative risks.
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饶腾子,王逾男,吴菁,尹爱华,麦明琴,钟燕芳.2011～2014年174例双胎妊娠产前诊断结果分析.中国产前诊断杂志,2014,6(4):11-14.
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