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645例羊膜腔穿刺产前诊断的临床分析 [中文引用][英文引用]

Clinical Analysis of Cases of Amniocentesis in Prenatal Diagnosis

作者(英文):Wang Yan  Feng Li-yun  Guo Yi  Jing Chun-li  Ma Yao 
单位(英文):Dalian Obstetrics and Gynecology Hospital 
关键词(英文):anbuicebtesis  prenatal diagnosis  karyotype analysis 
分类号:R714.53
出版年·卷·期(页码):2011·3·第3期(25-27)
DOI: 20110306
-----摘要:-------------------------------------------------------------------------------------------

目的 探讨羊水细胞染色体异常核型与产前诊断指征的关系为产前遗传咨询提供客观的实验依据方法 选取645例具备产前诊断指征的妊娠妇女行羊膜腔穿刺术及羊水细胞染色体核型检测结果 羊水细胞培养成功率为100%检出异常核型31异常率为4.8%21三体占全部异常核型检出率的35.5%近三分之一的孕妇伴有超声软指标异常以超声软指标异常及夫妇一方染色体异常和生育胎儿畸形史为指征的异常染色体检出率明显高于高龄妊娠?血清筛查高风险和21三体史结论 高龄孕妇及血清学筛查高风险都有进行产前诊断的必要性尤其对伴有超声软指标异常者建议其行产前诊断21三体占全部异常核型检出率的35.5%应重视21三体产前筛查及诊断以避免漏诊

-----英文摘要:---------------------------------------------------------------------------------------

Objective This study investigated the relationship between the human chromosomal abnormal karyotypes and prenatal diagnosis indication, in order to provide the objective experimental evidence useful for prenatal genetic counseling. Methods The chromosomal karyotypes of 645 cases of amniocentesis with prenatal diagnosis indication were analyzed. Results The success rate of amniotic cell culture was 100%. Chromosomal aberrations were observed in 31(4.8%) cases. Down syndrome fetuses account for 35.5%  Chromosomal aberrations in our study, nearly one third of which with abnormal soft markers in ultrasound examination. The corresponding relevance ratio of abnormal karyotype of the cases with abnormal soft markers in ultrasound examination and those with chromosomal abnormal karyotype in one of the couple and fetal malformation in previous pregnancies are significantly higher than other groups. Conclusion Prenatal diagnosis should be implemented for all pregnant women with high risk factors, especially those with abnormal soft markers in ultrasound examination. We should pay more attention to the prenatal diagnosis of Down syndrome.

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若需在您的论文中引用此文,请按以下格式著录参考文献:
中文著录格式: 王彦,冯丽云,郭邑,荆春丽,马瑶.645例羊膜腔穿刺产前诊断的临床分析.中国产前诊断杂志,2011,3(3):25-27.
英文著录格式: Wang,Yan,,Feng,Li-yun,,Guo,Yi,,Jing,Chun-li,,Ma,Yao.Clinical Analysis of Cases of Amniocentesis in Prenatal Diagnosis.No Title Settings,2011,3(3):25-27.

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